THE USE OF INTERIM DATA AND DATA MONITORING COMMITTEE RECOMMENDATIONS IN RANDOMIZED CONTROLLED TRIAL REPORTS: FREQUENCY, IMPLICATIONS AND POTENTIAL SOURCES OF BIAS

Abstract Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead Steamer to extended use of interim analysis or recommendations that could potentially bias trial resul

ABSTRACT: The objective was to determine, through indirect immunofluorescence reaction (RIFI, 1:64), the occurrence of IgG antibodies to Toxoplasma gondii and the risk factors associated with infection in C goats in the state of Sergipe.To this study were used 675 samples of blood of animals from 41 farms of the three state mesoregions from 2013 to

Hydrological drought forecasting plays a substantial role in water resources management.Hydrological drought highly affects the water allocation and hydropower generation.In this research, short term hydrological drought forecasted based on the hybridized of novel nature-inspired optimization algorithms and Artificial Neural Networks (ANN).For this

Radio frequency (RF)-based drone identification technologies have the Lip Balm advantages of long effective distances and low environmental dependence, which has become indispensable for drone surveillance systems.However, since drones operate in unlicensed frequency bands, a large number of co-frequency devices exist in these bands, which brings a